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KMID : 0355820160370010001
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Korean Journal of Oral Anatomy
2016 Volume.37 No. 1 p.1 ~ p.8
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Localization patterns of LYVE1 and CD31 in mice tongue development
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Sanjiv Neupane
Cho Jae-Min
Lee Sung-Won
Son Hyuk-Moon
Bae Yong-Hyun
Kim Sung-Hyun
Sohn Wern-Joo
Lee Young-Kyun
Jung Jae-Kwang
Kim Jae-Young
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Abstract
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Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE1) is a cell surface receptor on lymphatic endo?thelial cells hich is the earliest known marker of lymphatic endothelial commitment. Platelet endothelial cell adhesion molecule also known as cluster of differentiation 31 (CD31) is a well-known marker for blood vessel formation. In this study, we examined the localization patterns of LYVE1 and CD31 in the developing tongue at El4, El6, E17 and PN0, PN5, PN10, PN15 and PN20 to understand the detailed developmental processes of lymphangiogenesis along with vasculogenesis by immunostaining examinations. Our observations revealed that there were specific patterns of proteins localizations through developmental stages. At El4, LYVE1 was local?ized mainly in the ventral region along the median fibrous septum and laterally in between the genioglossus and hyoglossus muscle forming regions. The localization of CD31 was more ubiquitous in the developing tongue at E14. The localization pa竹erns of LYVE1 and CD31 showed more specified in the dorsal and ventral region at El 6. In addition, branching formation of the lymphatic and blood vessels were more evident. At E17, more dis?tinct localization patterns of LYVE1 and CD31 were observed in the intrinsic tongue muscles forming region. At later stages, the LYVE-1 and CD31 were mostly localized in the interface between the muscle fibers. Our results suggest that there would be relationships between lymphangiogenesis and vasculogenesis in developing mouse tongue. These normal developmental processes in lymphangiogenesis and vasculogenesis would be an excellent foundation for further studies in pathological conditions and tongue development malformations.
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KEYWORD
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Lymphangiogenesis, Vasculogenesis, Tongue development, Organogenesis
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